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Year : 2018  |  Volume : 24  |  Issue : 4  |  Page : 237-241

Effect of N-acetylcysteine on cochlear function in patients with chronic kidney disease undergoing hemodialysis

1 Department of Otolaryngology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Communication Disorders Research Center, Rehabilitation Sciences Institute, Isfahan University of Medical Sciences, Hezar Jarib St, Isfahan University, Isfahan, Iran

Correspondence Address:
Dr. Mohammad Shafieyan Sararoodi
No. 64, Bagh Ziar Street, Sohrevardi Street, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.INDIANJOTOL_6_18

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Objective: This study aimed to investigate the effect of N-acetylcysteine (NAC) on cochlear function in patients with chronic kidney disease (CKD). Methodology: The statistical population of this controlled clinical trial included all CKD patients. In total, 64 samples, selected from patients visiting the Dialysis Center of Al-Zahra Hospital from February 2017 to May 2017, were equally randomized into the intervention and control groups. At the baseline, the pure-tone audiometry (PTA) and Distortion Product Oto Acoustic Emissions (DP-OAE) tests were conducted. Then, NAC was administered in the intervention group for 8 weeks. Aforementioned hearing tests were repeated at the end of the interventions and results were compared. Finally, data analysis was carried out in SPSS. Results: Based on the mean scores of hearing threshold, there was no significant between-group difference in the speech discrimination score (SDS) speech reception threshold (SRT) of the left and right sides following NAC administration (P > 0.05). Comparison of the mean OAE following NAC administration showed a significant between-group difference, based on the mean signal/noise ratios (S/N 1000, 2000, and 4000) of the both right and left ears (P < 0.05). To compare the mean DP-OAE changes before and after the intervention between the two groups, the difference between pre- and post-intervention DP-OAE variables was first computed. Then, these changes were compared. A significant between-group difference was observed in S/N ratios of 1000, 2000, and 4000 Hz of the both right and left sides before and after the intervention (P < 0.05). In contrast, changes in other variables did not imply a significant between-group difference (P > 0.05). Conclusion: This study showed the effectiveness of NAC in improving cochlear function in 1, 2, and 4 KHz; whereas, it did not significantly affect the hearing threshold.

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