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Year : 2018  |  Volume : 24  |  Issue : 4  |  Page : 257-260

Effect of preemptive pregabalin for postoperative pain relief in myringoplasty

Department of ENT-HNS, Dhulikhel Hospital, Kathmandu University Hospital, Kavre, Nepal

Correspondence Address:
Dr. Ashish Dhakal
Department of ENT-HNS, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.INDIANJOTOL_88_18

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Context: Myringoplasty is a common surgical procedure done by ENT surgeons. Postoperative period requires use of analgesics which are being given on a regular basis. Aims: The aim of this study was to investigate the effect of preemptive pregabalin on postoperative pain reduction after endoscopic myringoplasty. Settings and Design: This was a prospective, experimental study conducted in the department of ENT and Head and Neck surgery in Dhulikhel Hospital, Kathmandu University Hospital, Kavre from September 2015 to December 2017. Subjects and Methods: Patient were randomly assigned to one of the two groups with 30 participants each by lottery method. Pregabalin group received capsule pregabalin 150 mg and placebo group were given Vitamin B capsule 1 h before surgery. Statistical Analysis Used: Normally distributed variables were analyzed with the Student's t-test and nonnormally distributed variables with the Mann–Whitney test. SPSS v. 21.0 for Windows (SPSS Inc., Chicago, USA) was used for the statistical data analysis. Results: Pain scores were significantly lower in pregabalin group as compared to placebo group at 6 h (U = 123, P < 0.01), 12 h (U = 107.5, P < 0.01), 24 h (U = 160.5, P < 0.01), and 48 h (U = 121.5, P < 0.01). Number of patients who required rescue analgesics and dosage was lower in pregabalin group than placebo group (P < 0.01). Conclusions: The preemptive administration of single dose of pregabalin 150 mg is an effective way to reduce postoperative pain and analgesic consumption in patients undergoing endoscopic myringoplasty.

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