| ORIGINAL ARTICLE |
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| Year : 2019 | Volume
: 25
| Issue : 3 | Page : 155-161 |
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Intranasal hyaluronic acid improves the audiological outcomes of children with otitis media with effusion
Davide Topazio1, Francesco Maria Passali1, Antonia Cama1, Federica Martino1, Roberta Di Mauro2, Angelo Tirabasso3, Theodoro Varakliotis4, Stefano Di Girolamo1
1 Department of Translational Medicine, Otolaryngology, University of Rome “Tor Vergata,” ,Rome, Italy
2 Department of Translational Medicine, Otolaryngology;Departement of System Medicine, Neuroscience Unit, University of Rome “Tor Vergata,” Rome, Italy
3 Department of Environmental and Occupational Medicine, National Institute for Insurance Against Accidents at Work (INAIL), Rome, Italy
4 Department of Applied Clinical Sciences and Biotechnology, L'Aquila University, Coppito, Italy
Correspondence Address:
Dr. Federica Martino
Viale Giulio Agricola, 6 00174 Rome
Italy
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/indianjotol.INDIANJOTOL_107_18
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Background/Aim: We evaluated the efficacy and compliance of a therapeutic approach based on intranasally-administered hyaluronic acid (HA) in the treatment of chronic otitis media with effusion (OME) in pediatric patients. Materials and Methods: Forty-four pediatric patients were enrolled and randomized into two groups: the first one (Group A) received a treatment based on HA and Group B was treated with saline solution only. Both therapies were intranasally administered by compressed-air nebulizer and Rinowash, a nebulizer designed to treat the upper airway structures. Patients were evaluated by medical history, otoscopy, pure-tone audiometry, and impedentiometry at 0 (T0), 4 (T1), 12 (T2), and 16 (T3) weeks. Results: The analysis of tympanometric and audiometric data, such as the evaluation of otoscopic improvements, showed significant differences between the two groups. After just 1 month of therapy, (T1) tympanometric evaluation showed greater improvements in Group A. Data on the audiometric threshold improvements, measured at different stages of the treatment, showed a greater improvement of the mean/median value of the auditory thresholds in patients treated with HA than in patients of Group B. Conclusion: The absence of side effects and the results observed make this therapeutic approach a potential valid alternative in the difficult long-term management of OME.
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