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Year : 2022  |  Volume : 28  |  Issue : 1  |  Page : 52-56

Changes of serum levels of Caspase-3 after trauma and ototoxic damage of the cochlea in rabbits: An in vivo study

1 ENT Clinic, University Hospital Mainz, Mainz, Germany
2 2nd ENT-Department of Aristotle University Thessaloniki, Thessaloniki, Greece
3 Department for Anaesthisiology and Intensive Care, Medical University of Graz, Graz, Austria

Correspondence Address:
Dr. Pavlos Pavlidis
ENT Clinic, University Hospital Mainz, Mainz
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.indianjotol_29_22

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Background: Caspase-3 is one of the most important enzymes for the regulation of apoptosis. Aims and Objectives: Aim of our study was to examine the changes in serum levels of this factor during apoptotic phenomena in the cochlea, caused by traumatic or ototoxic causes. Materials and Methods: A cohort of 24 rabbits was studied for this purpose for 31 days. Eight animals were implanted with a cochlear implant electrode (group A), 8 were treated with intramuscular amikacin for 14 days (group B) and another 8 were the control group (group C). In all groups DPOAEs and serum levels of caspase-3 were tested every second day. Results: Serum levels of caspase-3 rise immediately after implantation, while a 3-day latency in levels was seen in group B. Caspase-3-levels in both groups remained elevated until the 31st day of the experiment. Levels of caspase-3 showed a moderate negative correlation with DPAOE amplitudes. Conclusion: Caspase-3 rises after traumatic and ototoxic causes and moderately correlates with cochlear outer hair cell function in rabbits. Therefore, serum caspase-3 levels should be tested as a surrogate marker of structural integrity of the cochlea after trauma or administration of ototoxic drugs in humans as well.

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