Home Ahead of print Instructions Contacts
About us Current issue Submit article Advertise  
Editorial board Archives Subscribe Login   
Year : 2022  |  Volume : 28  |  Issue : 2  |  Page : 139-143

Ischemia-Modified Albumin Levels in Patients with Bell's palsy

1 Department of Otorhinolaryngology, University of Health Sciences, Umraniye Training and Research Hospital, İzmit, Turkey
2 Department of Otorhinolaryngology, Faculty of Medicine, Istanbul Medipol University, İzmit, Turkey
3 Department of Biochemistry, Istanbul Medipol University, Istanbul, Turkey
4 Department of Otolaryngology, Kocaeli State Hospital, İzmit, Turkey

Correspondence Address:
Dr. Ahmet Adnan Cirik
Department of Otorhinolaryngology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.indianjotol_4_22

Rights and Permissions

Background: Although several causes have been regarded as possible including viral, autoimmune, inflammatory, and vascular ischemia, the accurate etiology and pathophysiology of Bell's palsy (BP) remain unclear. The aim of the present article was to determine whether serum levels of ischemia-modified albumin (IMA) are associated with BP and if there is a posttreatment change in IMA levels. Materials and Methods: This was a prospective study enrolling 23 patients (10 males and 13 females; mean age: 44.71 ± 16.72 years; and range, 20–57 years) and 23 healthy individuals (12 males and 11 females; mean age: 37.91 ± 9.16 years; and range, 9–73 years) as the control group. Blood samples were obtained from the antecubital vein from all of the volunteers. Albumin cobalt binding test was used to obtain the IMA levels. Results: The mean IMA level was 0.38 ± 0.06 absorbance units in the study group at the time of diagnosis, 0.35 ± 0.07 absorbance units at the posttreatment period, and 0.35 ± 0.06 absorbance units in the control group. IMA levels of patients in posttreatment period were lower than the onset of illness. The result was statistically significant (P = 0.01). Conclusion: The data demonstrate that IMA decreased in BP with treatment. This is a preliminary study and we could not obtain results that clearly support the ischemic hypothesis of pathogenesis of BP; we think it gives an idea for further studies.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded3    
    Comments [Add]    

Recommend this journal